检索范围:
排序: 展示方式:
《医学前沿(英文)》 2023年 第17卷 第3期 页码 476-492 doi: 10.1007/s11684-022-0966-6
关键词: EIF4A1 G-quadruplex hepatocellular carcinoma tRNA-derived small RNA translation initiation
《医学前沿(英文)》 2022年 第16卷 第2期 页码 176-184 doi: 10.1007/s11684-021-0885-y
关键词: small noncoding RNAs epigenetic inheritance paternal intergenerational inherence extracellular vesicles
Blockage of receptor-interacting protein 2 expression by small interfering RNA in murine macrophages
LIU Hongchun, CAO Zhongwei, JIN Jianjun, WANG Jiyao
《医学前沿(英文)》 2008年 第2卷 第2期 页码 166-170 doi: 10.1007/s11684-008-0030-1
Gene silencing efficiency of shRNA expression vectors targeting Cx43
Cuihong ZHENG, Yunxia WU, Guangying HUANG, Wei WANG
《医学前沿(英文)》 2009年 第3卷 第2期 页码 130-135 doi: 10.1007/s11684-009-0030-9
关键词: RNA interference connexin 43 small hairpin RNA (shRNA) acupuncture
肿瘤特异性环状RNA来源抗原肽被证实存在于肝胆肿瘤中 Article
王文闻, 马莉丽 , 邢政, 苑廷淦, 包金霞, 朱妍静, 赵晓芳, 赵燕, 宗雅丽, 张雅妮, 莘似韵, 邱辛瑶, 杨帅, 王红阳, 高栋, 王鹏, 陈磊
《工程(英文)》 2023年 第22卷 第3期 页码 159-170 doi: 10.1016/j.eng.2022.06.008
关键词: 肿瘤抗原 患者来源肝胆肿瘤类器官 环状RNA 基于质谱的免疫肽组学
Ribozyme and the mechanisms that underlie RNA catalysis
Timothy J. Wilson,Yijin Liu,David M. J. Lilley
《化学科学与工程前沿(英文)》 2016年 第10卷 第2期 页码 178-185 doi: 10.1007/s11705-016-1558-2
基于RNA的生物防治——一种作物保护新模式 Review
Matthew Bramlett, Geert Plaetinck, Peter Maienfisch
《工程(英文)》 2020年 第6卷 第5期 页码 522-527 doi: 10.1016/j.eng.2019.09.008
关键词: 基于RNA的生物防治 RNA干扰(RNAi) 科罗拉多马铃薯甲虫(CPB) 玉米根虫(CRW) 大豆臭虫(SSB)
岩浆镍铜铂族矿床成矿过程中流体的作用——对小岩体超大型矿床的启示
张铭杰,汤庆艳,李文渊、余明、胡沛青、李建平
《中国工程科学》 2015年 第17卷 第2期 页码 40-49
超大型岩浆镍、铂族元素(PGE)硫化物矿床控制了Ni-PGE的资源量,本文根据地幔岩浆事件中Ni、Cu和PGE等在部分熔融、岩浆结晶和硫化物熔离过程的行为,讨论了岩浆Ni-Cu-PGE硫化物矿床的成矿岩浆类型与规模、成矿金属元素聚集的方式、岩浆演化过程中硫饱和度与硫化物液相不混溶的控制因素,探讨了流体对成矿金属的运移聚集作用等。认为地幔大规模的高度部分熔融(即要求高Mg岩浆)促使地幔硫化物及橄榄石中巨量的Ni和PGE进入岩浆,硫化物熔离富集成矿金属形成大型层状(或通道)岩体赋存的超大型Ni-Cu-PGE硫化物矿床;地幔超临界流体可能大范围内搬运聚集大量Ni-PGE金属元素,对岩浆硫化物矿床成矿可能有重要贡献,是小规模岩浆(小岩体)成矿的可能机制。
关键词: 流体;小岩体;成矿作用
Xuefei Ma, Wei Zhang, Rong Zhang, Jingming Li, Shufen Li, Yunlin Ma, Wen Jin, Kankan Wang
《医学前沿(英文)》 2019年 第13卷 第3期 页码 330-343 doi: 10.1007/s11684-017-0557-0
Association of gene variants with juvenile amyotrophic lateral sclerosis
《医学前沿(英文)》 doi: 10.1007/s11684-023-1005-y
关键词: TRMT2B amyotrophic lateral sclerosis mitochondrial complex I tRNA methylation reactive oxygen species
null
《医学前沿(英文)》 2017年 第11卷 第4期 页码 502-508 doi: 10.1007/s11684-017-0590-z
Although the efficacy of nucleos(t)ide analogue (NA) has been confirmed for treatment of chronic hepatitis B, long-term therapy has been recommended due to the high frequency of off-therapy viral DNA rebound and disease relapse. In this review, the RNA virion-like particles of hepatitis B virus (HBV) are integrated into the life cycle of HBV replication, and the potential significance of serum HBV RNA is systematically described. The production of HBV RNA virion-like particles should not be blocked by NA; in this regard, serum HBV RNA is found to be a suitable surrogate marker for the activity of intrahepatic covalently closed circular DNA (cccDNA), particularly among patients receiving NA therapy. Therefore, the concept of virological response is redefined as persistent loss of serum HBV DNA and HBV RNA. In contrast to hepatitis B surface antigen (HBsAg) that can originate from either the cccDNA or the integrated HBV DNA fragment, serum HBV RNA, with pregenomic RNA origination, can only be transcribed from cccDNA. Therefore, the loss of serum HBV RNA would likely be a promising predicator for safe drug discontinuation. The clinical status of consistent loss of serum HBV RNA accompanied with low serum HBsAg levels might be implicated as a “para-functional cure,” a status nearly close to the functional cure of chronic hepatitis B, to distinguish the “functional cure” characterized as serum HBsAg loss with or without anti-HBs seroconversion.
关键词: chronic hepatitis B serum HBV RNA nucleos(t)ide analogs virological response para-functional cure
《医学前沿(英文)》 doi: 10.1007/s11684-023-1017-7
关键词: single-cell RNA-seq glioma radial glia primitive oligodendrocyte precursor cell immune escape
Construction and identification of lentiviral RNA interference vector of rat leptin receptor gene
Zhengjuan LIU, Jie BIAN, Yuchuan WANG, Yongli ZHAO, Dong YAN, Xiaoxia WANG
《医学前沿(英文)》 2009年 第3卷 第1期 页码 57-60 doi: 10.1007/s11684-009-0003-z
标题 作者 时间 类型 操作
5′-tiRNA-Gln inhibits hepatocellular carcinoma progression by repressing translation through the interaction with eukaryotic initiation factor 4A-I
期刊论文
Paternal environmental exposure-induced spermatozoal small noncoding RNA alteration meditates the intergenerational
期刊论文
Blockage of receptor-interacting protein 2 expression by small interfering RNA in murine macrophages
LIU Hongchun, CAO Zhongwei, JIN Jianjun, WANG Jiyao
期刊论文
Gene silencing efficiency of shRNA expression vectors targeting Cx43
Cuihong ZHENG, Yunxia WU, Guangying HUANG, Wei WANG
期刊论文
肿瘤特异性环状RNA来源抗原肽被证实存在于肝胆肿瘤中
王文闻, 马莉丽 , 邢政, 苑廷淦, 包金霞, 朱妍静, 赵晓芳, 赵燕, 宗雅丽, 张雅妮, 莘似韵, 邱辛瑶, 杨帅, 王红阳, 高栋, 王鹏, 陈磊
期刊论文
Ribozyme and the mechanisms that underlie RNA catalysis
Timothy J. Wilson,Yijin Liu,David M. J. Lilley
期刊论文
Overexpressed long noncoding RNA CRNDE with distinct alternatively spliced isoforms in multiple cancers
Xuefei Ma, Wei Zhang, Rong Zhang, Jingming Li, Shufen Li, Yunlin Ma, Wen Jin, Kankan Wang
期刊论文
Potential use of serum HBV RNA in antiviral therapy for chronic hepatitis B in the era of nucleos(t)ide
null
期刊论文
immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq
期刊论文